Syndecan-4 is required for early-stage repair responses during zebrafish heart regeneration.

ABSTRACT:

Background

The healing process after a myocardial infarction (MI) in humans involves complex events that replace damaged tissue with a fibrotic scar. The affected cardiac tissue may lose its function permanently. In contrast, zebrafish display a remarkable capacity for scar-free heart regeneration. Previous studies have revealed that syndecan-4 (SDC4) regulates inflammatory response and fibroblast activity following cardiac injury in higher vertebrates. However, whether and how Sdc4 regulates heart regeneration in highly regenerative zebrafish remains unknown.

Methods and results

This study showed that sdc4 expression was differentially regulated during zebrafish heart regeneration by transcriptional analysis. Specifically, sdc4 expression increased rapidly and transiently i

SUBMITTER: Lai ZY 

PROVIDER: S-EPMC11068835 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature