Knockdown of NADK promotes LUAD ferroptosis via NADPH/FSP1 axis.

ABSTRACT:

Background

Lung cancer is a serious threat to human health and is the first leading cause of cancer death. Ferroptosis, a newly discovered form of programmed cell death associated with redox homeostasis, is of particular interest in the lung cancer, given the high oxygen environment of lung cancer. NADPH has reducing properties and therefore holds the potential to resist ferroptosis. Resistance to ferroptosis exists in lung cancer, but the role of NADK in regulating ferroptosis in lung cancer has not been reported yet.

Methods

Immunohistochemistry (IHC) was used to analyse the expression of NADK in 86 cases of lung adenocarcinoma(LUAD) and adjacent tissues, and a IHC score was assigned to each sample. Chi-square and kaplan-meier curve was performed to analyse the differences

SUBMITTER: Meng X 

PROVIDER: S-EPMC11068837 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature