Misfolded protein deposits in Parkinson's disease and Parkinson's disease-related cognitive impairment, a [¹¹C]PBB3 study.

ABSTRACT: Parkinson's disease (PD) is associated with aggregation of misfolded α-synuclein and other proteins, including tau. We designed a cross-sectional study to quantify the brain binding of [¹¹C]PBB3 (a ligand known to bind to misfolded tau and possibly α-synuclein) as a proxy of misfolded protein aggregation in Parkinson's disease (PD) subjects with and without cognitive impairment and healthy controls (HC). In this cross-sectional study, nineteen cognitively normal PD subjects (CN-PD), thirteen cognitively impaired PD subjects (CI-PD) and ten HC underwent [¹¹C]PBB3 PET. A subset of the PD subjects also underwent PET imaging with [¹¹C](+)DTBZ to assess dopaminergic denervation and [¹¹C]PBR28 to assess neuroinflammation. Compared to HC, PD subjects sh

SUBMITTER: Matarazzo M 

PROVIDER: S-EPMC11068893 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature