Increased tumor-infiltrating plasmacytoid dendritic cells express high levels of PD-L2 and affect CD8⁺ T lymphocyte infiltration in human laryngeal squamous cell carcinoma.

ABSTRACT: The infiltration and prognostic significance of tumor-infiltrating plasmacytoid dendritic cells (TI-pDC) have been elucidated in various human solid cancers. However, the infiltrating patterns and functional importance of TI-pDC in laryngeal squamous cell carcinoma (LSCC) remain unknown. In this study, flow cytometric analyses were conducted to characterize the infiltration of dendritic cells and T lymphocytes, along with their respective subgroups in tumor tissues (TT), para-carcinoma tissues (PT), and peripheral blood (PB) from LSCC patients. Immunohistochemical staining for CD4 and CD8, as well as immunofluorescence staining for CD123, were performed on serial tissue sections to investigate the co-localization of TI-pDC and tumor-infiltrating T lymphocytes (TIL) within the tumor microen

SUBMITTER: Ji Y 

PROVIDER: S-EPMC11068930 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature