Renal Disease in Metabolic Syndrome: the Hidden Role of Intrarenal Ischemia.

ABSTRACT:

Introduction

The pathogenesis of renal disease in obesity and metabolic syndrome (MS) is mostly unknown. This is in part because of the limited information about renal morphological changes in these conditions. We evaluated renal histology in subjects with MS and those without MS, who are participants in the European Nephrectomy Biobank (ENBiBA) project.

Methods

MS was defined with at least 3 of the following criteria: (i) body mass index (BMI) ≥27 kg/m²; (ii) prediabetes: fasting glucose of 100-125 mg/dl or HbA1c >5.7%; (iii) systolic or diastolic blood pressure >140/90 mm Hg or the use of medications; and (iv) triglycerides >150 mg/dl or high-density lipoprotein cholesterol <40 (in men) or 50 mg/dl (in women). The absence of these criteria defined patients witho

SUBMITTER: Rodriguez-Rodriguez R 

PROVIDER: S-EPMC11068944 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature