Relevance of Tacrolimus Trough Concentration and Hepatitis E virus Genetic Changes in Kidney Transplant Recipients With Chronic Hepatitis E.

ABSTRACT:

Introduction

Hepatitis E virus (HEV) can cause chronic infection (≥3 months) and cirrhosis in immunocompromised patients, especially kidney transplant recipients. Low alanine aminotransferase (ALT) levels and high HEV intrahost diversity have previously been associated with evolution toward chronicity in these patients. We hypothesized that additional clinical and viral factors could be associated with the risk of chronic HEV infection.

Methods

We investigated a series of 27 kidney transplant recipients with HEV infection, including 20 patients with chronic hepatitis E.

Results

High tacrolimus trough concentration at diagnosis was the most relevant marker associated with chronic hepatitis E (9.2 vs. 6.4 ng/ml, P = 0.04). Most HEV genetic changes selected during

SUBMITTER: Leon-Janampa N 

PROVIDER: S-EPMC11069011 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature