Early Rituximab as an Add-On Therapy in Children With the Initial Episode of Nephrotic Syndrome.

ABSTRACT:

Introduction

The approximately 70% 12-month relapse in children experiencing the initial episode of steroid-sensitive nephrotic syndrome (SSNS) is a significant concern, with over 50% developing frequent relapses or steroid-dependent nephrotic syndrome (FRNS/SDNS). There is a lack of strategies to reduce relapse after the onset. Whether early administration of rituximab, which effectively reduces relapses in FRNS/SDNS, may be a solution has not been evaluated.

Methods

A prospective, multicenter, open-label, single-arm trial was conducted in China, with a 12-month follow-up. Children aged 1 to 18 years with the first episode of nephrotic syndrome (NS) were screened for eligibility. Proteinuria was evaluated daily using dipsticks. A dose of 375 mg/m² of rituximab wa

SUBMITTER: Liu J 

PROVIDER: S-EPMC11069012 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature