Direct metagenomics investigation of non-surgical hard-to-heal wounds: a review.

ABSTRACT:

Background

Non-surgical chronic wounds, including diabetes-related foot diseases (DRFD), pressure injuries (PIs) and venous leg ulcers (VLU), are common hard-to-heal wounds. Wound evolution partly depends on microbial colonisation or infection, which is often confused by clinicians, thereby hampering proper management. Current routine microbiology investigation of these wounds is based on in vitro culture, focusing only on a limited panel of the most frequently isolated bacteria, leaving a large part of the wound microbiome undocumented.

Methods

A literature search was conducted on original studies published through October 2022 reporting metagenomic next generation sequencing (mNGS) of chronic wound samples. Studies were eligible for inclusion if they applied 16 S rRNA meta

SUBMITTER: Morsli M 

PROVIDER: S-EPMC11069288 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature