Genetic association of inflammatory marker GlycA with lung function and respiratory diseases.

ABSTRACT: Association of circulating glycoprotein acetyls (GlycA), a systemic inflammation biomarker, with lung function and respiratory diseases remain to be investigated. We examined the genetic correlation, shared genetics, and potential causality of GlycA (N = 115,078) with lung function and respiratory diseases (N = 497,000). GlycA showed significant genetic correlation with FEV1 (r_g = -0.14), FVC (r_g = -0.18), asthma (r_g= 0.21) and COPD (r_g= 0.31). We consistently identified ten shared loci (including chr3p21.31 and chr8p23.1) at both SNP and gene level revealing potential shared biological mechanisms involving ubiquitination, immune response, Wnt/β-catenin signaling, cell growth and differentiation in tissues or cells including blood, epithelium,

SUBMITTER: Guo Y 

PROVIDER: S-EPMC11069551 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature