Sex-specific circulating unconventional neutrophils determine immunological outcome of auto-inflammatory Behcet's uveitis.

ABSTRACT: Neutrophils are the most abundant immune cells that first respond to insults in circulation. Although associative evidence suggests that differences in neutrophils may be linked to the sex-specific vulnerability of inflammatory diseases, mechanistic links remain elusive. Here, we identified extensive sex-specific heterogeneity in neutrophil composition under normal and auto-inflammatory conditions at single-cell resolution. Using a combination of single-cell RNA sequencing analysis, neutrophil-specific genetic knockouts and transfer experiments, we discovered dysregulation of two unconventional (interferon-α responsive and T cell regulatory) neutrophil subsets leading to male-biased incidence, severity and poor prognosis of auto-inflammatory Behçet's uveitis. Genome-wide association study

SUBMITTER: Wang Q 

PROVIDER: S-EPMC11069589 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature