Epithelial overexpression of IL-33 induces eosinophilic esophagitis dependent on IL-13.

ABSTRACT:

Background

Eosinophilic esophagitis (EoE) is an increasingly common inflammatory condition of the esophagus; however, the underlying immunologic mechanisms remain poorly understood. The epithelium-derived cytokine IL-33 is associated with type 2 immune responses and elevated in esophageal biopsy specimens from patients with EoE.

Objective

We hypothesized that overexpression of IL-33 by the esophageal epithelium would promote the immunopathology of EoE.

Methods

We evaluated the functional consequences of esophageal epithelial overexpression of a secreted and active form of IL-33 in a novel transgenic mouse, EoE33. EoE33 mice were analyzed for clinical and immunologic phenotypes. Esophageal contractility was assessed. Epithelial cytokine responses were analyzed in three

SUBMITTER: Masuda MY 

PROVIDER: S-EPMC11070306 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature