Gut microbiome and metabolome to discover pathogenic bacteria and probiotics in ankylosing spondylitis.

ABSTRACT:

Objective

Previous research has partially revealed distinct gut microbiota in ankylosing spondylitis (AS). In this study, we performed non-targeted fecal metabolomics in AS in order to discover the microbiome-metabolome interface in AS. Based on prospective cohort studies, we further explored the impact of the tumor necrosis factor inhibitor (TNFi) on the gut microbiota and metabolites in AS.

Methods

To further understand the gut microbiota and metabolites in AS, along with the influence of TNFi, we initiated a prospective cohort study. Fecal samples were collected from 29 patients with AS before and after TNFi therapy and 31 healthy controls. Metagenomic and metabolomic experiments were performed on the fecal samples; moreover, validation experiments were conducted based on

SUBMITTER: Lai Y 

PROVIDER: S-EPMC11070502 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature