Relative biological effectiveness of oxygen ion beams in the rat spinal cord: Dependence on linear energy transfer and dose and comparison with model predictions.

ABSTRACT:

Background and purpose

Ion beams exhibit an increased relative biological effectiveness (RBE) with respect to photons. This study determined the RBE of oxygen ion beams as a function of linear energy transfer (LET) and dose in the rat spinal cord.

Materials and methods

The spinal cord of rats was irradiated at four different positions of a 6 cm spread-out Bragg-peak (LET: 26, 66, 98 and 141 keV/µm) using increasing levels of single and split oxygen ion doses. Dose-response curves were established for the endpoint paresis grade II and based on ED₅₀ (dose at 50 % effect probability), the RBE was determined and compared to model predictions.

Results

When LET increased from 26 to 98 keV/µm, ED₅₀ decreased from 17.2 ± 0.3 Gy to 13.5 ± 0.4 Gy for singl

SUBMITTER: Glowa C 

PROVIDER: S-EPMC11070926 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature