Regional differences in outcomes with ablation versus drug therapy for atrial fibrillation: Results from the CABANA trial.

ABSTRACT:

Background

The finding of unexpected variations in treatment benefits by geographic region in international clinical trials raises complex questions about the interpretation and generalizability of trial findings. We observed such geographical variations in outcome and in the effectiveness of atrial fibrillation (AF) ablation versus drug therapy in the Catheter Ablation vs Antiarrhythmic Drug Therapy for Atrial Fibrillation (CABANA) trial. This paper describes these differences and investigates potential causes.

Methods

The examination of treatment effects by geographic region was a prespecified analysis. CABANA enrolled patients from 10 countries, with 1,285 patients at 85 North American (NA) sites and 919 at 41 non-NA sites. The primary endpoint was a composite of death, d

SUBMITTER: Cappato R 

PROVIDER: S-EPMC11070931 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature