Association between pre-biologic T2-biomarker combinations and response to biologics in patients with severe asthma.

ABSTRACT:

Background

To date, studies investigating the association between pre-biologic biomarker levels and post-biologic outcomes have been limited to single biomarkers and assessment of biologic efficacy from structured clinical trials.

Aim

To elucidate the associations of pre-biologic individual biomarker levels or their combinations with pre-to-post biologic changes in asthma outcomes in real-life.

Methods

This was a registry-based, cohort study using data from 23 countries, which shared data with the International Severe Asthma Registry (May 2017-February 2023). The investigated biomarkers (highest pre-biologic levels) were immunoglobulin E (IgE), blood eosinophil count (BEC) and fractional exhaled nitric oxide (FeNO). Pre- to approximately 12-month post-biologic change

SUBMITTER: Porsbjerg CM 

PROVIDER: S-EPMC11070939 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature