Association of rs35006907 Polymorphism with Risk of Dilated Cardiomyopathy in Han Chinese Population.

ABSTRACT:

Background

Several investigations have demonstrated the association of MTSS1 with left ventricular (LV) structure and function. A recently published study has even revealed that rs35006907 was associated with both MTSS1 expression and the risk of dilated cardiomyopathy (DCM).

Objective

Our study intended to investigate the relationship between rs35006907 and the risk of DCM in the Han Chinese population.

Methods

A total of 529 DCM and 600 healthy controls were recruited. We conducted genotyping for rs35006907 in all participants. Gene association studies were performed to assess the association between rs35006907 and the risk of DCM. A series of functional assays including western blot, realtime PCR and firefly luciferase reporter gene assays were conduc

SUBMITTER: Yang C 

PROVIDER: S-EPMC11071056 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature