A computational approach for deciphering the interactions between proximal and distal gene regulators in GC B-cell response.

ABSTRACT: Delineating the intricate interplay between promoter-proximal and -distal regulators is crucial for understanding the function of transcriptional mediator complexes implicated in the regulation of gene expression. The present study aimed to develop a computational method for accurately modeling the spatial proximal and distal regulatory interactions. Our method combined regression-based models to identify key regulators through gene expression prediction and a graph-embedding approach to detect coregulated genes. This approach enabled a detailed investigation of the gene regulatory mechanisms for germinal center B cells, accompanied by dramatic rearrangements of the genome structure. We found that while the promoter-proximal regulatory elements were the principal regulators of gene express

SUBMITTER: Park SJ 

PROVIDER: S-EPMC11071120 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature