High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats.

ABSTRACT: Obesity, associated with the intake of a high-fat diet (HFD), and anxiety are common among those living in modern urban societies. Recent studies suggest a role of microbiome-gut-brain axis signaling, including a role for brain serotonergic systems in the relationship between HFD and anxiety. Evidence suggests the gut microbiome and the serotonergic brain system together may play an important role in this response. Here we conducted a nine-week HFD protocol in male rats, followed by an analysis of the gut microbiome diversity and community composition, brainstem serotonergic gene expression (tph2, htr1a, and slc6a4), and anxiety-related defensive behavioral responses. We show that HFD intake decreased alpha diversity and altered the community composition of the gut microbiome in associatio

SUBMITTER: de Noronha SISR 

PROVIDER: S-EPMC11071217 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature