WNT3 promotes chemoresistance to 5-Fluorouracil in oral squamous cell carcinoma via activating the canonical β-catenin pathway.

ABSTRACT:

Background

5-Fluorouracil (5FU) is a primary chemotherapeutic agent used to treat oral squamous cell carcinoma (OSCC). However, the development of drug resistance has significantly limited its clinical application. Therefore, there is an urgent need to determine the mechanisms underlying drug resistance and identify effective targets. In recent years, the Wingless and Int-1 (WNT) signaling pathway has been increasingly studied in cancer drug resistance; however, the role of WNT3, a ligand of the canonical WNT signaling pathway, in OSCC 5FU-resistance is not clear. This study delved into this potential connection.

Methods

5FU-resistant cell lines were established by gradually elevating the drug concentration in the culture medium. Differential gene expressions between parenta

SUBMITTER: Zhang X 

PROVIDER: S-EPMC11071218 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature