D-mannose alleviates intervertebral disc degeneration through glutamine metabolism.

ABSTRACT:

Background

Intervertebral disc degeneration (IVDD) is a multifaceted condition characterized by heterogeneity, wherein the balance between catabolism and anabolism in the extracellular matrix of nucleus pulposus (NP) cells plays a central role. Presently, the available treatments primarily focus on relieving symptoms associated with IVDD without offering an effective cure targeting its underlying pathophysiological processes. D-mannose (referred to as mannose) has demonstrated anti-catabolic properties in various diseases. Nevertheless, its therapeutic potential in IVDD has yet to be explored.

Methods

The study began with optimizing the mannose concentration for restoring NP cells. Transcriptomic analyses were employed to identify the mediators influenced by mannose, with th

SUBMITTER: Dong ZL 

PROVIDER: S-EPMC11071241 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature