Elucidating the association of obstructive sleep apnea with brain structure and cognitive performance.

ABSTRACT:

Background

Obstructive sleep apnea (OSA) is a pervasive, chronic sleep-related respiratory condition that causes brain structural alterations and cognitive impairments. However, the causal association of OSA with brain morphology and cognitive performance has not been determined.

Methods

We conducted a two-sample bidirectional Mendelian randomization (MR) analysis to investigate the causal relationship between OSA and a range of neurocognitive characteristics, including brain cortical structure, brain subcortical structure, brain structural change across the lifespan, and cognitive performance. Summary-level GWAS data for OSA from the FinnGen consortium was used to identify genetically predicted OSA. Data regarding neurocognitive characteristics were obtained from published

SUBMITTER: Bao J 

PROVIDER: S-EPMC11071327 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature