Neurochemical and Neurophysiological Effects of Intravenous Administration of <i>N,N-</i>Dimethyltryptamine in Rats.

ABSTRACT: N,N-dimethyltryptamine (DMT) is a serotonergic psychedelic that is being investigated clinically for the treatment of psychiatric disorders. Although the neurophysiological effects of DMT in humans are well-characterized, similar studies in animal models as well as data on the neurochemical effects of DMT are generally lacking, which are critical for mechanistic understanding. In the current study, we combined behavioral analysis, high-density (32-channel) electroencephalography, and ultra-high-performance liquid chromatography-tandem mass spectrometry to simultaneously quantify changes in behavior, cortical neural dynamics, and levels of 17 neurochemicals in medial prefrontal and somatosensory cortices before, during, and after intravenous administration of three different d

SUBMITTER: Glynos NG 

PROVIDER: S-EPMC11071436 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature