Exploring the PET in vivo generator ¹³⁴Ce as a theranostic match for ²²⁵Ac.

ABSTRACT:

Purpose

The radionuclide pair cerium-134/lanthanum-134 (¹³⁴Ce/¹³⁴La) was recently proposed as a suitable diagnostic counterpart for the therapeutic alpha-emitter actinium-225 (²²⁵Ac). The unique properties of ¹³⁴Ce offer perspectives for developing innovative in vivo investigations not possible with ²²⁵Ac. In this work, ²²⁵Ac- and ¹³⁴Ce-labeled tracers were directly compared using internalizing and slow-internalizing cancer models to evaluate their in vivo comparability, progeny meandering, and potential as a matched theranostic pair for clinical translation. Despite being an excellent chemical match, ¹³⁴Ce/¹³⁴La has limitations to the setting of quantitative positron emission tomogra

SUBMITTER: Bauer D 

PROVIDER: S-EPMC11071455 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature