Colorectal Cancer Stem Cell Subtypes Orchestrate Distinct Tumor Microenvironments.

ABSTRACT: Several classification systems have been developed to define tumor subtypes in colorectal cancer (CRC). One system proposes that tumor heterogeneity derives in part from distinct cancer stem cell populations that co-exist as admixtures of varying proportions. However, the lack of single cell resolution has prohibited a definitive identification of these types of stem cells and therefore any understanding of how each influence tumor phenotypes. Here were report the isolation and characterization of two cancer stem cell subtypes from the SW480 CRC cell line. We find these cancer stem cells are oncogenic versions of the normal Crypt Base Columnar (CBC) and Regenerative Stem Cell (RSC) populations from intestinal crypts and that their gene signatures are consistent with the "Admixture" and oth

SUBMITTER: Hosohama L 

PROVIDER: S-EPMC11071458 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature