RIPK3 promotes neuronal survival by suppressing excitatory neurotransmission during CNS viral infection.

ABSTRACT: While recent work has identified roles for immune mediators in the regulation of neural activity, the capacity for cell intrinsic innate immune signaling within neurons to influence neurotransmission remains poorly understood. However, the existing evidence linking immune signaling with neuronal function suggests that modulation of neurotransmission may serve previously undefined roles in host protection during infection of the central nervous system. Here, we identify a specialized function for RIPK3, a kinase traditionally associated with necroptotic cell death, in preserving neuronal survival during neurotropic flavivirus infection through the suppression of excitatory neurotransmission. We show that RIPK3 coordinates transcriptomic changes in neurons that suppress neuronal glutamate si

SUBMITTER: Estevez I 

PROVIDER: S-EPMC11071512 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature