C-reactive protein-based tuberculosis triage testing: a multi-country diagnostic accuracy study.

ABSTRACT:

Rationale

C-reactive protein (CRP)-based tuberculosis (TB) screening is recommended for people with HIV (PWH). However, its performance among people without HIV and in diverse settings is unknown.

Objectives

In a multi-country study, we aimed to determine whether CRP meets the minimum accuracy targets (sensitivity ≥90%, specificity ≥70%) for an effective TB triage test.

Methods/measurements

Consecutive outpatient adults with cough ≥2 weeks from five TB endemic countries in Africa and Asia had baseline blood collected for point-of-care CRP testing and HIV and diabetes screening. Sputum samples were collected for Xpert MTB/RIF Ultra (Xpert) testing and culture. CRP sensitivity and specificity (5 mg/L cut-point) was determined in reference to sputum test results and comp

SUBMITTER: Derendinger B 

PROVIDER: S-EPMC11071588 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature