Aβ_1-42 peptides blunt the adenosine A_2A receptor-mediated control of the interplay between P₂X₇ and P₂Y₁ receptors mediated calcium responses in astrocytes.

ABSTRACT: The contribution of astrocytes to Alzheimer's disease (AD) is still ill defined. AD involves an abnormal accumulation of amyloid-β peptides (Aβ) and increased production of danger signals such as ATP. ATP can direct or indirectly, through its metabolism into adenosine, trigger adaptive astrocytic responses resulting from intracellular Ca²⁺ oscillations. AD also triggers an upregulation of astrocytic adenosine A_2A receptors (A_2AR), which blockade prevents memory dysfunction in AD. We now investigated how Aβ peptides affect ATP-mediated Ca²⁺ responses in astrocytes measured by fluorescence live-cell imaging and whether A_2AR control astrocytic Ca²⁺ responses mediated by ATP receptors, mainly P₂X₇R and P

SUBMITTER: Dias L 

PROVIDER: S-EPMC11071907 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature