A review of the pleiotropic actions of the IFN-inducible CXC chemokine receptor 3 ligands in the synovial microenvironment.

ABSTRACT: Chemokines are pivotal players in instigation and perpetuation of synovitis through leukocytes egress from the blood circulation into the inflamed articulation. Multitudinous literature addressing the involvement of the dual-function interferon (IFN)-inducible chemokines CXCL9, CXCL10 and CXCL11 in diseases characterized by chronic inflammatory arthritis emphasizes the need for detangling their etiopathological relevance. Through interaction with their mutual receptor CXC chemokine receptor 3 (CXCR3), the chemokines CXCL9, CXCL10 and CXCL11 exert their hallmark function of coordinating directional trafficking of CD4⁺ T_H1 cells, CD8⁺ T cells, NK cells and NKT cells towards inflammatory niches. Among other (patho)physiological processes including infection, c

SUBMITTER: Dillemans L 

PROVIDER: S-EPMC11071919 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature