PiR-1919609 Is an Ideal Potential Target for Reversing Platinum Resistance in Ovarian Cancer.

ABSTRACT:

Purpose

PIWI-interacting RNAs (piRNAs) are a type of noncoding small RNA that can interact with PIWI-like RNA-mediated gene silencing (PIWIL) proteins to affect biological processes such as transposon silencing through epigenetic effects. Recent studies have found that piRNAs are widely dysregulated in tumors and associated with tumor progression and a poor prognosis. Therefore, this study aimed to investigate the effect of piR-1919609 on the proliferation, apoptosis, and drug resistance of ovarian cancer cells.

Methods

In this study, we used small RNA sequencing to screen and identify differentially expressed piRNAs in primary ovarian cancer, recurrent ovarian cancer, and normal ovaries. A large-scale verification study was performed to verify the expression of piR-1919609

SUBMITTER: Yan Y 

PROVIDER: S-EPMC11072069 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature