Phenazine derivatives attenuate the stemness of breast cancer cells through triggering ferroptosis.

ABSTRACT: Breast cancer stem cells (BCSCs) are positively correlated with the metastasis, chemoresistance, and recurrence of breast cancer. However, there are still no drugs targeting BCSCs in clinical using for breast cancer treatment. Here, we tried to screen out small-molecule compounds targeting BCSCs from the phenazine library established by us before. We focused on the compounds without affecting cell viability and screened out three potential compounds (CPUL119, CPUL129, CPUL149) that can significantly attenuate the stemness of breast cancer cells, as evident by the decrease of stemness marker expression, CD44⁺/CD24^- subpopulation, mammary spheroid-formation ability, and tumor-initiating capacity. Additionally, these compounds suppressed the metastatic ability of breast

SUBMITTER: Yang Y 

PROVIDER: S-EPMC11072418 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature