Stem cell antigen-1⁺cell-derived fibroblasts are crucial for cardiac fibrosis during heart failure.

ABSTRACT:

Aims

Mesenchymal stem cells (MSCs) present in the heart cannot differentiate into cardiomyocytes, but may play a role in pathological conditions. Therefore, the aim of this study was to scrutinise the role and mechanism of MSC differentiation in vivo during heart failure.

Methods and results

We performed single-cell RNA sequencing of total non-cardiomyocytes from murine and adult human hearts. By analysing the transcriptomes of single cells, we illustrated the dynamics of the cell landscape during the progression of heart hypertrophy, including those of stem cell antigen-1 (Sca1)⁺ stem/progenitor cells and fibroblasts. By combining genetic lineage tracing and bone marrow transplantation models, we demonstrated that non-bone marrow-derived Sca1⁺ cells gi

SUBMITTER: Tao T 

PROVIDER: S-EPMC11073062 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature