Dietary Na⁺ depletion up-regulates NKCC1 expression and enhances electrogenic Cl^- secretion in rat proximal colon.

ABSTRACT: The corticosteroid hormone, aldosterone, markedly enhances K⁺ secretion throughout the colon, a mechanism critical to its role in maintaining overall K⁺ balance. Previous studies demonstrated that basolateral NKCC1 was up-regulated by aldosterone in the distal colon specifically to support K⁺ secretion-which is distinct from the more well-established role of NKCC1 in supporting luminal Cl^- secretion. However, considerable segmental variability exists between proximal and distal colonic ion transport processes, especially concerning their regulation by aldosterone. Furthermore, delineating such region-specific effects has important implications for the management of various gastrointestinal pathologies. Experiments were therefore designed to deter

SUBMITTER: Nickerson AJ 

PROVIDER: S-EPMC11073443 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature