Myeloid- and epithelial-derived RELMα contribute to tissue repair following lung helminth infection.

ABSTRACT: Soil-transmitted helminth (STH) infections impact billions of individuals globally; however, there is a need to clarify the long-term impacts of these infections on pulmonary health owing to their transient migration and subsequent damage to the lungs. In mouse models of these infections using Nippostrongylus brasiliensis, lung pathology persists at later time points post single infection. These studies also indicate the persistent transcriptional expression of resistin-like molecule α (RELMα), an immunomodulatory protein induced in type 2 immunity and alternatively activated macrophages. Using constitutive and tamoxifen-inducible cell-specific RELMα knockout mouse strains, we identified that epithelial- and myeloid-derived RELMα protein remained elevated at 30 days post infection a

SUBMITTER: Sveiven SN 

PROVIDER: S-EPMC11073794 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature