Contribution of parasite and host genotype to immunopathology of schistosome infections.

ABSTRACT:

Background

The role of pathogen genotype in determining disease severity and immunopathology has been studied intensively in microbial pathogens including bacteria, fungi, protozoa and viruses but is poorly understood in parasitic helminths. The medically important blood fluke Schistosoma mansoni is an excellent model system to study the impact of helminth genetic variation on immunopathology. Our laboratory has demonstrated that laboratory schistosome populations differ in sporocyst growth and cercarial production in the intermediate snail host and worm establishment and fecundity in the vertebrate host. Here, we (i) investigate the hypothesis that schistosome genotype plays a significant role in immunopathology and related parasite life history traits in the vertebrate mouse host

SUBMITTER: Jutzeler KS 

PROVIDER: S-EPMC11073996 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature