Chikungunya virus infection in human microglial C20 cells induces mitochondria-mediated apoptosis.

ABSTRACT:

Introduction

Chikungunya virus (CHIKV) infection is associated with acute clinical manifestations and chronic joint inflammation. CHIKV has emerged as a significant causative agent of central nervous system (CNS) complications, including encephalitis and related sequelae. Microglial cells, crucial for immune responses and tissue repair in the CNS, play a vital role in the host response to viral infections, with their activation potentially leading to either protection or pathology. In this study, the infection biology of CHIKV in the C20 human microglial cell line was investigated.

Methods

The permissiveness of C20 cells to CHIKV infection was assessed, and viral replication kinetics were compared to Vero E6 cells. Cytopathic effects of CHIKV infection on C20 cells were exam

SUBMITTER: Kumar N 

PROVIDER: S-EPMC11074397 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature