Application of Metagenomic Next-Generation Sequencing in the Diagnosis of Infectious Keratitis.

ABSTRACT:

Purpose

To determine the advantages of next-generation metagenomic sequencing (mNGS) technology in the diagnosis and treatment of infectious keratitis (IK).

Methods

A total of 287 patients with IK admitted to the Department of Ophthalmology of Nanjing First Hospital between August 2018 and December 2022 were analyzed retrospectively, and the pathogenic causes, etiological characteristics, detection, treatment methods, and efficacy were summarized.

Results

Trauma and foreign matter were the most common causes of IK (144 patients, 50.2%). Of the 287 patients, 228 (79.4%) were diagnosed with a specific etiology, including 110 (48.2%) fungal infections, 44 (19.3%) viral infections, 42 (18.4%) mixed infections, and 30 (13.2%) bacterial infections. Filamentous fungi represe

SUBMITTER: Pan XY 

PROVIDER: S-EPMC11074721 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature