The effect of somatic mutations in mitochondrial DNA on the survival of patients with primary brain tumors.

ABSTRACT:

Aim

To assess the presence of mitochondrial (mt) DNA somatic mutations, determine the relationship between clinicopathological characteristics and mutations, and assess the survival outcomes in Malay patients with primary brain tumors.

Methods

The study enrolled 54 patients with primary brain tumors. DNA extracted from paired tissue and blood samples was subjected to Sanger sequencing to identify alterations in the entire mtDNA. The associations between clinicopathological characteristics and mutations were evaluated. Cox-regression multivariate analysis was conducted to identify factors significantly associated with survival, and Kaplan-Meier analysis was used to compare the survival of patients with and without mutations.

Results

Overall, 29.6% of the patients harbo

SUBMITTER: Khair SZNM 

PROVIDER: S-EPMC11074945 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature