Macrophage/microglia-producing transient increase of platelet-activating factor is involved in neuropathic pain.

ABSTRACT: Peripheral nerve injury (PNI) induces debilitating neuropathic pain symptoms, such as tactile allodynia. Accumulating evidence suggests that the expression levels of various transcripts and proteins are drastically changed after PNI. Recent lipidome analysis demonstrates increased levels of diverse lipids in chronic pain conditions. We show that PNI transiently increases platelet-activating factor (PAF) levels, a potent inflammatory phospholipid mediator, in the dorsal root ganglia (DRG) and spinal cord. We revealed that macrophage and microglia-specific PAF-producing enzyme LPLAT9/LPCAT2 knockout mice (Cx3cr1^CreERT2;Lpcat2^flox/flox) failed to develop mechanical allodynia and to increase PAF levels in the DRG and spinal cord after PNI. Moreover, we obser

SUBMITTER: Yamamoto S 

PROVIDER: S-EPMC11074981 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature