Functional regulation of microglia by vitamin B12 alleviates ischemic stroke-induced neuroinflammation in mice.

ABSTRACT: Ischemic stroke is the second leading cause of death and disability worldwide, and efforts to prevent stroke, mitigate secondary neurological damage, and promote neurological recovery remain paramount. Recent findings highlight the critical importance of microbiome-related metabolites, including vitamin B12 (VB12), in alleviating toxic stroke-associated neuroinflammation. Here, we showed that VB12 tonically programmed genes supporting microglial cell division and activation and critically controlled cellular fatty acid metabolism in homeostasis. Intriguingly, VB12 promoted mitochondrial transcriptional and metabolic activities and significantly restricted stroke-associated gene alterations in microglia. Furthermore, VB12 differentially altered the functions of microglial subsets during the

SUBMITTER: Ge Y 

PROVIDER: S-EPMC11075062 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature