Protein-Protein interactive networks identified in bronchoalveolar lavage of severe compared to nonsevere asthma.

ABSTRACT:

Introduction

Previous bronchoalveolar lavage fluid (BALF) proteomic analysis has evaluated limited numbers of subjects for only a few proteins of interest, which may differ between asthma and normal controls. Our objective was to examine a more comprehensive inflammatory biomarker panel in quantitative proteomic analysis for a large asthma cohort to identify molecular phenotypes distinguishing severe from nonsevere asthma.

Methods

Bronchoalveolar lavage fluid from 48 severe and 77 nonsevere adult asthma subjects were assessed for 75 inflammatory proteins, normalized to BALF total protein concentration. Validation of BALF differences was sought through equivalent protein analysis of autologous sputum. Subjects' data, stratified by asthma severity, were analysed by standard st

SUBMITTER: Hastie AT 

PROVIDER: S-EPMC11075125 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature