Comparison of quantitative whole body PET parameters on [⁶⁸Ga]Ga-PSMA-11 PET/CT using ordered Subset Expectation Maximization (OSEM) vs. bayesian penalized likelihood (BPL) reconstruction algorithms in men with metastatic castration-resistant prostate cancer.

ABSTRACT:

Background

PSMA PET/CT is a predictive and prognostic biomarker for determining response to [¹⁷⁷Lu]Lu-PSMA-617 in patients with metastatic castration resistant prostate cancer (mCRPC). Thresholds defined to date may not be generalizable to newer image reconstruction algorithms. Bayesian penalized likelihood (BPL) reconstruction algorithm is a novel reconstruction algorithm that may improve contrast whilst preventing introduction of image noise. The aim of this study is to compare the quantitative parameters obtained using BPL and the Ordered Subset Expectation Maximization (OSEM) reconstruction algorithms.

Methods

Fifty consecutive patients with mCRPC who underwent [⁶⁸Ga]Ga-PSMA-11 PET/CT using OSEM reconstruction to assess suitability for [¹⁷⁷

SUBMITTER: Ayati N 

PROVIDER: S-EPMC11075202 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature