Evidence of SARS-CoV-2 convergent evolution in immunosuppressed patients treated with antiviral therapies.

ABSTRACT:

Background

The factors contributing to the accelerated convergent evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are not fully understood. Unraveling the contribution of viral replication in immunocompromised patients is important for the early detection of novel mutations and developing approaches to limit COVID-19.

Methods

We deep sequenced SARS-CoV-2 RNA from 192 patients (64% hospitalized, 39% immunosuppressed) and compared the viral genetic diversity within the patient groups of different immunity and hospitalization status. Serial sampling of 14 patients was evaluated for viral evolution in response to antiviral treatments.

Results

We identified hospitalized and immunosuppressed patients with significantly higher levels of viral geneti

SUBMITTER: Feng S 

PROVIDER: S-EPMC11075269 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature