An association study of m6A methylation with major depressive disorder.

ABSTRACT:

Objective

To find the relationship between N6-methyladenosine (m6A) genes and Major Depressive Disorder (MDD).

Methods

Differential expression of m6A associated genes between normal and MDD samples was initially identified. Subsequent analysis was conducted on the functions of these genes and the pathways they may affect. A diagnostic model was constructed using the expression matrix of these differential genes, and visualized using a nomogram. Simultaneously, an unsupervised classification method was employed to classify all patients based on the expression of these m6A associated genes. Following this, common differential genes among different clusters were computed. By analyzing the functions of the common differential expressed genes among clusters, the role of m6A-relat

SUBMITTER: Li Y 

PROVIDER: S-EPMC11075325 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature