Early adversity causes sex-specific deficits in perforant pathway connectivity and contextual memory in adolescent mice.

ABSTRACT:

Background

Early life adversity impairs hippocampal development and function across diverse species. While initial evidence indicated potential variations between males and females, further research is required to validate these observations and better understand the underlying mechanisms contributing to these sex differences. Furthermore, most of the preclinical work in rodents was performed in adult males, with only few studies examining sex differences during adolescence when such differences appear more pronounced. To address these concerns, we investigated the impact of limited bedding (LB), a mouse model of early adversity, on hippocampal development in prepubescent and adolescent male and female mice.

Methods

RNA sequencing, confocal microscopy, and electron microscop

SUBMITTER: Islam R 

PROVIDER: S-EPMC11075329 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature