Disruption of maternal vascular remodeling by a fetal endoretrovirus-derived gene in preeclampsia.

ABSTRACT:

Background

Preeclampsia, one of the most lethal pregnancy-related diseases, is associated with the disruption of uterine spiral artery remodeling during placentation. However, the early molecular events leading to preeclampsia remain unknown.

Results

By analyzing placentas from preeclampsia, non-preeclampsia, and twin pregnancies with selective intrauterine growth restriction, we show that the pathogenesis of preeclampsia is attributed to immature trophoblast and maldeveloped endothelial cells. Delayed epigenetic reprogramming during early extraembryonic tissue development leads to generation of excessive immature trophoblast cells. We find reduction of de novo DNA methylation in these trophoblast cells results in selective overexpression of maternally imprinted genes, inclu

SUBMITTER: Gong X 

PROVIDER: S-EPMC11075363 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature