CCR2-dependent CX3CR1+ colonic macrophages promote <i>Enterococcus faecalis</i> dissemination.

ABSTRACT: Enterococci are common commensal bacteria that colonize the gastrointestinal tracts of most mammals, including humans. Importantly, these bacteria are one of the leading causes of nosocomial infections. This study examined the role of colonic macrophages in facilitating Enterococcus faecalis infections in mice. We determined that depletion of colonic phagocytes resulted in the reduction of E. faecalis dissemination to the gut-draining mesenteric lymph nodes. Furthermore, we established that trafficking of monocyte-derived CX3CR1-expressing macrophages contributed to E. faecalis dissemination in a manner that was not reliant on CCR7, the conventional receptor involved in lymphatic migration. Finally, we showed that E. faecalis mutants with impaired intracellular

SUBMITTER: Jennings KC 

PROVIDER: S-EPMC11075457 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature