Peptidoglycan fragment release and NOD activation by commensal Neisseria species from humans and other animals.

ABSTRACT: Neisseria gonorrhoeae, a human restricted pathogen, releases inflammatory peptidoglycan (PG) fragments that contribute to the pathophysiology of pelvic inflammatory disease. The genus Neisseria is also home to multiple species of human- or animal-associated Neisseria that form part of the normal microbiota. Here we characterized PG release from the human-associated nonpathogenic species Neisseria lactamica and Neisseria mucosa and animal-associated Neisseria from macaques and wild mice. An N. mucosa strain and an N. lactamica strain were found to release limited amounts of the proinflammatory monomeric PG fragments. However, a single amino acid difference in the PG fragment permease AmpG resulted in increased PG fragment release in a

SUBMITTER: Harris-Jones TN 

PROVIDER: S-EPMC11075463 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature