Evolutionary analyses of intrinsically disordered regions reveal widespread signals of conservation.

ABSTRACT: Intrinsically disordered regions (IDRs) are segments of proteins without stable three-dimensional structures. As this flexibility allows them to interact with diverse binding partners, IDRs play key roles in cell signaling and gene expression. Despite the prevalence and importance of IDRs in eukaryotic proteomes and various biological processes, associating them with specific molecular functions remains a significant challenge due to their high rates of sequence evolution. However, by comparing the observed values of various IDR-associated properties against those generated under a simulated model of evolution, a recent study found most IDRs across the entire yeast proteome contain conserved features. Furthermore, it showed clusters of IDRs with common "evolutionary signatures," i.e. patte

SUBMITTER: Singleton MD 

PROVIDER: S-EPMC11075841 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature