Unraveling the genetics of arsenic toxicity with cellular morphology QTL.

ABSTRACT: The health risks that arise from environmental exposures vary widely within and across human populations, and these differences are largely determined by genetic variation and gene-by-environment (gene-environment) interactions. However, risk assessment in laboratory mice typically involves isogenic strains and therefore, does not account for these known genetic effects. In this context, genetically heterogenous cell lines from laboratory mice are promising tools for population-based screening because they provide a way to introduce genetic variation in risk assessment without increasing animal use. Cell lines from genetic reference populations of laboratory mice offer genetic diversity, power for genetic mapping, and potentially, predictive value for in vivo experimentation in genetically

SUBMITTER: O'Connor C 

PROVIDER: S-EPMC11075906 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature