Gut microbiota and autoimmune neurologic disorders: a two-sample bidirectional Mendelian randomization study.

ABSTRACT:

Background

Increasing evidence has suggested that alterations in the gut microbiome are correlated with autoimmune neurologic disorders, yet the causal relationship between them has yet to be established.

Methods

From the published genome-wide association study (GWAS) summary statistics, we obtained data on the gut microbiota and three autoimmune neurologic disorders (Multiple Sclerosis, Guillain-Barré Syndrome, and Myasthenia Gravis). We then implemented a two-sample Mendelian Randomization (MR) to determine the causal relationship between the gut microbiota and the diseases. To validate the results, we conducted a series of sensitivity analyses. Finally, to verify the direction of causality, a reverse-causality analysis was done.

Results

We discovered that a higher

SUBMITTER: Zhang M 

PROVIDER: S-EPMC11076763 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature